生物活性
PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。
靶点信息
| p70 S6K1 (Cell-free assay) | | | | |
| 160 nM | | | | |
化学数据
| 目录号 | A11755 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 390.4 |
| Formula | C19H21F3N6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1255517-76-0 |
| Synonyms | PF4708671, PF-4708671 |
| SMILES | CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F |
溶解度
| In vitro (25°C) | DMSO | 30 mg/mL (76.84 mM) |
| Water | Insoluble |
| Ethanol | 8 mg/mL (20.49 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.61 mL | 128.07 mL | 256.15 mL |
| 0.5 mM | 5.12 mL | 25.61 mL | 51.23 mL |
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
