GSK3008348(hydrochloride)是一种小分子整联蛋白αvβ6拮抗剂，在荧光偏振检测中对人a6蛋白亲和力（pIC50）为8.1，在细胞粘连检测中，其亲合性分别为:ανβ6(pIC50=8.4);ανβ3(pIC50=6);ανβ5(pIC50=6.9);ανβ8(pIC50=7.7)。
CAS：1629249-40-6
分子式：C29H37N5O2.xHCl
分子量：
纯度：98%
存储：Store at -20°C

Background:

GSK 3008348 (hydrochloride) is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7).

[1]. Anderson Niall Andrew, et al. Preparation of naphthyridine derivatives useful as αvβ6 integrin antagonists. From PCT Int. Appl. (2014), WO 2014154725 A1 20141002.