Protein kinase C? (PKC?) is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase involved in diverse signaling pathways, including those involved in neuronal signaling, cytoskeletal function, and inflammation.
CAS：182683-50-7
分子式：C37H65N9O13
分子量：844
纯度：98%
存储：Store at -20°C

Background:

Protein kinase C? (PKC?) is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase involved in diverse signaling pathways, including those involved in neuronal signaling, cytoskeletal function, and inflammation.[1] PKC? inhibitor peptide is a synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKC?.[2] It selectively and reversibly inhibits the translocation of PKC? to intracellular membranes, blocking activation.[2] PKC? inhibitor peptide is commonly used in cells to evaluate the role of PKC? in various cellular responses.[3],[4],[5]

Reference:
[1]. Toker, A. Signaling through protein kinase C. Frontiers in Bioscience 3, d1134-d1147 (1998).
[2]. Johnson, J.A., Gray, M.O., Chen, C.H., et al. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. The Journal of Biological Chemisty 271(40), 24962-24966 (1996).
[3]. Schuster, D.J., Kitto, K.F., Overland, A.C., et al. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. Journal of Neuroscience 33(33), 13538-13546 (2013).
[4]. Thomspon, J.W., Dave, K.R., Saul, I., et al. Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. PLoS One 8(9), 1-12 (2013).
[5]. Obis, T., Besalduch, N., Hurtado, E., et al. The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: Location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Mol.Brain (2015).