生物活性
CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。
靶点信息
化学数据
| 目录号 | A12582 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 443.31 |
| Formula | C17H11F6N7O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1393477-72-9 |
| Synonyms | KPT330, KPT 330 |
| SMILES | C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F |
溶解度
| In vitro (25°C) | DMSO | 78 mg/mL (175.94 mM) |
| Water | Insoluble |
| Ethanol | 36 mg/mL (81.21 mM) |
| In vivo | 2% DMSO+40%PEG 300+5% Tween80 +ddH2O | 3 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.56 mL | 112.79 mL | 225.58 mL |
| 0.5 mM | 4.51 mL | 22.56 mL | 45.12 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.56 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
