6-Thioinosine

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6-Thioinosine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	574-25-4
规格:	98%
分子量:	284.29

包装与价格：

包装	价格(元)
10mg	询价
50mg	询价

6-?Thioinosine (6TI) 是一种嘌呤抗代谢物，为抗脂肪形成剂，能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL，CD36，aP2 和 LXRα 的 mRNA 水平。
CAS：574-25-4
分子式：C10H12N4O4S
分子量：284.29
纯度：98%
存储：Store at -20°C

Background:

6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.