5-HT4 antagonist 1

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5-HT4 antagonist 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	261766-73-8
规格:	98%
分子量:	480.62

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价

5-HT4antagonist1是一个5-HT4受体拮抗剂，其pKi值为9.6。
CAS：261766-73-8
分子式：C23H36N4O5S
分子量：480.62
纯度：98%
存储：Store at -20°C

Background:

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1].

[1]. Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.