QX77是分子伴侣介导的自噬(CMA)激活剂。
CAS：1798331-92-6
分子式：C16H13ClN2O2
分子量：300.74
纯度：98%
存储：Store at -20°C

Background:

QX77 is a chaperone-mediated autophagy (CMA) activator.

Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].

[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.