Mal-PEG2-VCP-Eribulin

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2130869-18-8
规格:	98%
分子量:	1374.57

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价

Mal-PEG2-VCP-Eribulin 由 ADC linker (Mal-PEG2-VCP) 和 Eribulin 偶联而成。Eribulin 是一种独特的微管 (microtubule) 抑制剂，具有抗肿瘤活性。Mal-PEG2-VCP-Eribulin 可用于偶联抗体。
CAS：2130869-18-8
分子式：C70H99N7O21
分子量：1374.57
纯度：98%
存储：Store at -20°C

Background:

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1. [2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.