inhibitor of the breast cancer stem cells
CAS：1378872-36-6
分子式：C13H10Cl3N3O2
分子量：346.6
纯度：98%
存储：Store at -20°C

Background:

ML239 is the best-in-class inhibitor of the breast cancer stem cells with an IC₅₀ = 1.16 µM. [1]

ML239 was a selective inhibitor an IC₅₀= 1.18 µM against HMLE_sh_ECad, demonstrated a >23-fold selectivity over the control line, and was toxic to another CSC-like line, HMLE_shTwist, and a breast carcinoma cell line, MDA-MB-231. Five genes (ATP6V0C, PKM2, PPDPF, RPL23, and SERINC2) were differentially regulated in HMLE_sh_GFP after treatment with ML239. Gene expression studies conducted with ML239-treated cells showed altered gene expression in the NF-κB pathway in the HMLE_sh_ECad line but not in the isogenic control line. ML239 was selectively toxic toward another CSC-like cell line, HMLE_Twist, and the breast cancer line, MDA-MB-231. Similar to the results observed in the HMLE_sh_ECad cell line, ML239 was potently toxic, inhibiting HMLE_Twist with an IC₅₀