Selpercatinib是一种有效的RET激酶抑制剂，抑制RET(WT)，RET(V804M)和RET(G810R)，IC50分别为14.0nM，24.1nM和530.7nM，详细信息请参考专利文献WO2018071447A1中的化合物Example163。具有抗肿瘤作用。
CAS：2152628-33-4
分子式：C29H31N7O3
分子量：525.6
纯度：98%
存储：Store at -20°C

Background:

Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2].

[1]. Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1. [2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018.