E3ligaseLigand-LinkerConjugates4是一种合成化合物,包含E3泛素连接酶配体与PROTAC连接物,可以将靶蛋白与泛素化机制结合起来。
CAS:1797406-81-5
分子式:C32H47N7O8S
分子量:689.82
纯度:98%
存储:Store at -20°C
Background:
E3 ligase Ligand-Linker Conjugates 4 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chemical Biology (2015), 10(8), 1770-1777.