SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。
CAS：944153-47-3
分子式：C16H14ClNO2
分子量：287.74
纯度：98%
存储：Store at -20°C

Background:

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington’s disease and familial Parkinson’s disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington’s disease cell and Drosophila melanogaster models, which suggests therapeutic potential.

[1]. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.