NKL22是HDAC抑制剂
CAS：537034-15-4
分子式：C19H23N3O2
分子量：325.4
纯度：98%
存储：Store at -20°C

Background:

NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN. [1]

[1]. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.