CDK2-IN-4 是一种有效选择性的 CDK2 抑制剂，对 CDK2/cyclin A 的 IC50 值为 44 nM，选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
CAS：2079895-42-2
分子式：C23H18N6O2S
分子量：442.49
纯度：98%
存储：Store at -20°C

Background:

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1]. cdk2/cyclin A|44 nM (IC50)|Cdk1/cyclin B|86 μM (IC50)

[1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.