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Guanidine hydrochloride(Guanidinium chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guanidine hydrochloride(Guanidinium chloride)图片
CAS NO:50-01-1
规格:98%
分子量:95.53
包装与价格:
包装价格(元)
10g询价
50g询价

Guanidine盐酸盐是蛋白代谢产物和蛋白变性剂,由鸟嘌呤氧化形成。
CAS:50-01-1
分子式:CH6ClN3
分子量:95.53
纯度:98%
存储:Store at -20°C

Background:

Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (>1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].




[1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4. [2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10.


 
 
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