D-3263hydrochloride是一种可口服的TRPM8激动剂。
CAS：1008763-54-9
分子式：C21H32ClN3O3
分子量：409.95
纯度：98%
存储：Store at -20°C

Background:

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH[1].

[1]. enteric-coated TRPM8 agonist D-3263 hydrochloride