BometololHydrochloride是一种beta-adrenergic阻滞剂，可用于高血压等心血管疾病的研究。
CAS：65023-16-7
分子式：C25H33ClN2O7
分子量：508.99
纯度：98%
存储：Store at -20°C

Background:

Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.

Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats[1].

[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12.