6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
CAS：120013-56-1
分子式：C23H27NO3
分子量：365.5
纯度：98%
存储：Store at -20°C

Background:

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).