SGC-iMLLT是一种有效、选择性的MLLT1/3-histone相互作用抑制剂，与MLLT1YD上的Kac/Kcr结合位点结合，对MLLT1YD(ENL/YEATS1)(IC50,0.26 μM;Kd,0.129 μM)和MLLT3YD(AF9/YEATS3)(Kd,0.077 μM)具有很高的亲和性。
CAS：2255338-25-9
分子式：C22H24N6O
分子量：388.47
纯度：98%
存储：Store at -20°C

Background:

SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1]. IC50: 0.26 μM (MLLT1 YD)[1]Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]

[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.