PROTACBETdegrader-2是一种强效的溴域及末端外(BET)蛋白的降解剂，在RS4;11细胞中测得其对细胞生长的IC50值为9.6nM，并能实现肿瘤消退。
CAS：2093388-33-9
分子式：C41H42N10O6
分子量：770.84
纯度：98%
存储：Store at -20°C

Background:

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.