EP1013是一种广谱的caspase选择性抑制剂，可用于1型糖尿病研究。
CAS：223568-55-6
分子式：C18H23FN2O6
分子量：382.38
纯度：98%
存储：Store at -20°C

Background:

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].

[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.