GLX351322

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GLX351322

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CAS NO:	835598-94-2
规格:	98%
分子量:	431.51

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

GLX351322是一种NADPH氧化酶4(NADPHoxidase4)抑制剂，在NOX4过表达的细胞中，抑制过氧化氢的产生，IC50值为5μM。
CAS：835598-94-2
分子式：C21H25N3O5S
分子量：431.51
纯度：98%
存储：Store at -20°C

Background:

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).

GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].

[1]. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18.