Tinostamustine HCl

An alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule
CAS：1793059-58-1
分子式：C19H29Cl3N4O2
分子量：451.82
纯度：98%
存储：Store at -20°C

Background:

Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. EDO-S101 is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents.

Reference:

[1].? Mehrling T, Chen Y. The Alkylating-HDAC Inhibition Fusion Principle: Taking
[2]. Chemotherapy to the Next Level with the First in Class Molecule EDO-S101.
[3]. Anticancer Agents Med Chem. 2015;16(1):20-8. PubMed PMID: 25980817.