Imipenem is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria (MICs range from 0.5-2 μg/ml for E.
CAS：74431-23-5
分子式：C12H17N3O4S.H2O
分子量：317.4
纯度：98%
存储：Store at -20°C

Background:

Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3].

参考文献:
[1]. Zhanel GG, et al. Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects. Can J Infect Dis. 1998 Jul;9(4):215-28.
[2]. Jacoby GA, et al. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82.
[3]. Balibar CJ, et al. cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology. 2010 May;156(Pt 5):1372-83.