OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase)
CAS：1681056-61-0
分子式：C28H25N3O6S2
分子量：563.64
纯度：98%
存储：Store at -20°C

Background:

OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.[1] It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.
Reference:
[1]. Ortiz-Meoz, R.F., Jiang, J., Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015).