HLE inhibitor
CAS：344930-95-6
分子式：C27H32N4O7S
分子量：556.63
纯度：98%
存储：Store at -20°C

Background:

High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC₅₀= 3.9 nM). Displays species-selectivity (K_ivalues are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID₅₀= 2.8 mg/kg) and reduces infarct size in anin vivoacute model of coronary ischemia-reperfusion injury. Orally active.