MC-Val-Cit-PAB-Auristatin E

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2055896-77-8
规格:	98%
分子量:	1287.65

MC-Val-Cit-PAB-Auristatin E 是基于季铵的生物可逆连接，用于靶向递送，可以改善药代动力学和治疗指数。MC-Val-Cit-PAB-Auristatin E 用于体外和体内有效且稳定的抗体-药物偶联物 (antibody-drug conjugates) 以治疗各种疾病或病症。
CAS：2055896-77-8
分子式：C68H108N11O13
分子量：1287.65
纯度：98%
存储：Store at -20°C

Background:

MC-Val-Cit-PAB-Auristatin E has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-Auristatin E is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.