Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.
CAS：1353550-13-6
分子式：C26H26N6O2S
分子量：486.59
纯度：98%
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Background:

Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.

Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].

参考文献:
[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.2016 Jul;76(11):1153-7.