Ro-24-0238是一种有效的plateletactivatingfactor(PAF)拮抗剂和thromboxanesynthesis的抑制剂,可用于减轻由血小板活化因子得释放导致的炎症和损伤。
CAS:120555-31-9
分子式:C27H36N2O2
分子量:420.59
纯度:98%
存储:Store at -20°C
Background:
Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.
Pretreatment with 3 mg/kg Ro 24-0238 and 3 mg/kg WEB 2086 decreases the accumulation of neutrophils within the mucosa in rats[1].
[1]. Will PC, et al. Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents Actions. 1991 Sep;34(1-2):181-4.