Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。
CAS：852329-66-9
分子式：C10H20BN3O3
分子量：241.1
纯度：98%
存储：Store at -20°C

Background:

Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.

Dutogliptin is highly water soluble (>2000 mg/mL), has low cellular permeability, exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. The compound is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].

[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. [2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.