(+)-Praeruptorin A is a coumarin derivative originally isolated from P.
CAS：73069-27-9
分子式：C21H22O7
分子量：386.4
纯度：98%
存储：Store at -20°C

Background:

(+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum. It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 µM and IL-6 at concentrations ranging from 25 to 100 µM. It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 µM, respectively. Topical administration of (+)-praeruptorin A (0.3 µmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation.