PF-06840003是高度选择的有口服活性的IDO-1抑制剂。
CAS：198474-05-4
分子式：C12H9FN2O2
分子量：232.21
纯度：98%
存储：Store at -20°C

Background:

PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor.

PF-06840003 reverses IDO-1-induced T-cell anergy in vitro[1].

PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours[1].

[1]. Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr4863.