PDE4 inhibitor
CAS：1013750-77-0
分子式：C20H20N4O4S
分子量：412.5
纯度：98%
存储：Store at -20°C

Background:

ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

ML-030 is potent in cell-based assay with an EC50 value of 18.7 nM[1].

参考文献:
[1]. Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92.