Chaetoglobosin A is a mycotoxic cytochalasin that was first isolated from the marine-derived endophytic fungus C.
CAS:50335-03-0
分子式:C32H36N2O5
分子量:528.6
纯度:98%
存储:Store at -20°C
Background:
Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration[1].
参考文献:
[1]. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.