DFMTI(MK5435)

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DFMTI(MK5435)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	864864-86-8
规格:	98%
分子量:	368.38

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价
50mg	询价
100mg	询价

DFMTI能够完全阻止rmGlu1L757V谷氨酸反应。
CAS：864864-86-8
分子式：C20H18F2N4O
分子量：368.38
纯度：98%
存储：Store at -20°C

Background:

DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.