NGI-1是一种细胞渗透性抑制剂。
CAS：790702-57-7
分子式：C17H22N4O3S2
分子量：394.51
纯度：98%
存储：Store at -20°C

Background:

NGI-1 is a cell permeable inhibitor.

NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].

[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.