(S)-Rasagiline (TVP1022) 甲磺酸盐是S-构型Rasagiline,对MAO-B的活性弱。
CAS:202464-88-8
分子式:C13H17NO3S
分子量:267.34
纯度:98%
存储:Store at -20°C
Background:
(S)-Rasagiline (TVP1022) mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.
[1]. Ertracht O, et al. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion. Br J Pharmacol. 2011 Jun;163(4):755-69.
[2]. Berdichevski A, et al. TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther. 2010 Feb;332(2):413-20.