SBI-115

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SBI-115

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CAS NO:	882366-16-7
规格:	98%
分子量:	340.78

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

SBI-115是一种TGR5(GPCR19)拮抗剂。SBI-115通过抑制TGR5降低多囊性肝病的肝囊肿形成。
CAS：882366-16-7
分子式：C14H13ClN2O4S
分子量：340.78
纯度：98%
存储：Store at -20°C

Background:

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1].

SBI-115 (100-200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes[1]. Cell Proliferation Assay[1] Cell Line: shRNA-transfected ADPKD cholangiocytes

[1]. Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218.