Sultriecin is a fungal metabolite originally isolated from S.
CAS:131774-59-9
分子式:C23H34O8P.Na
分子量:492.5
纯度:98%
存储:Store at -20°C
Background:
Sultriecin is a fungal metabolite originally isolated from S. roseiscleroticus. It is active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml). Sultriecin is cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml, respectively). It also inhibits RNA and protein synthesis in L1210 leukemia cells (IC50s = 5.5 and 2.4 μg/ml, respectively). Sultriecin (0.1-10 mg/kg) increases survival time in a B16/F10 syngeneic mouse melanoma model and a P388 murine leukemia model.