N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine.
CAS：41515-13-3
分子式：C15H19Cl2N3O2
分子量：344.2
纯度：98%
存储：Store at -20°C

Background:

N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine . N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).