BMS 182874 hydrochloride is a potent, selective, and competitive non-peptide endothelin ETAR antagonist. It exhibits > 1000-fold selectivity over ETB receptors. BMS 182874 hydrochloride inhibits ET-1-induced pressor response in vivo. It inhibits ET-1-induced pressor response, and also inhibits ET-1-induced longitudinal muscle contraction in vitro. References: Katyal T, Garg A, Budhiraja RD. Combination of daidzein, hemin and bms182874 halts the progression of diabetes-induced experimental nephropathy. Endocr Metab Immune Disord Drug Targets. 2013 Jun;13(2):152-62. PubMed PMID: 23701217.

纯度：≥98%

CAS：1215703-04-0