Becampanel(AMP397)是有效的AMPA拮抗剂，也是一种抗癫痫药。
CAS：188696-80-2
分子式：C10H11N4O7P
分子量：330.19
纯度：98%
存储：Store at -20°C

Background:

Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.

Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9[1].

Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo[1].

[1]. Suter W, et al. Genotoxicity assessment of the antiepileptic drug AMP397, an Ames-positive aromatic nitro compound. Mutat Res. 2002 Jul 25;518(2):181-94.