CH7057288是一种有效的选择性TRK抑制剂。
CAS：2095616-82-1
分子式：C32H31N3O5S
分子量：569.67
纯度：98%
存储：Store at -20°C

Background:

CH7057288 is a potent and selective TRK inhibitor.

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer[1].

[1]. Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.