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NO-Indomethacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NO-Indomethacin图片
CAS NO:301838-28-8
规格:98%
分子量:620.1
包装与价格:
包装价格(元)
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NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor.
CAS:301838-28-8
分子式:C28H30ClN3O9S
分子量:620.1
纯度:98%
存储:Store at -20°C

Background:

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.


 
 
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