C-176(STING inhibitor 1)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	314054-00-7
规格:	98%
分子量:	358.09

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
50mg	询价
100mg	询价

C-176是干扰素基因刺激受体(STING)的强效共价抑制剂。
CAS：314054-00-7
分子式：C11H7IN2O4
分子量：358.09
纯度：98%
存储：Store at -20°C

Background:

C-176 is a strong and covalent mouse STING inhibitor.

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].

Notably, treatment of Trex1-/- mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. The three-month trial conducted with C-176 in Trex1-/- mice demonstrated marked amelioration of various signs of systemic inflammation[1].

[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.