SKF96067是一种可逆的H+/K+-ATPase抑制剂。
CAS：115607-61-9
分子式：C21H22N2O2
分子量：334.41
纯度：98%
存储：Store at -20°C

Background:

SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.

SKF96067 inhibits K+-stimulated ATPase activity competitively with respect to the activating action K+, with a Ki value of 0.39 ± 0.05 μM. SKF96067 also inhibits hydrogen ion transport. SKF96067 inhibits ATPase activity with an IC50 value of 60 ± 10 μM at pH 7.0, in the presence of 100 mM NaCl and 1 mM KCl[1].

[1]. Keeling DJ, et al. SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem Pharmacol. 1991 Jun 21;42(1):123-30.