NQO1 substrate 作为一种高效的NQO1底物,可能会成为治疗NQO1过表达的、耐药型非小细胞肺癌 (NSCLC) 的新选择。
CAS:2304503-05-5
分子式:C13H2F2N4O
分子量:268.18
纯度:98%
存储:Store at -20°C
Background:
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].
[1]. Wu X, et al. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61(24):11280-11297.