UK51656是一种calcium拮抗剂，IC50值为4nM。
CAS：88150-59-8
分子式：C22H28ClN3O6
分子量：465.93
纯度：98%
存储：Store at -20°C

Background:

UK51656 is a calcium antagonist with IC50 of 4 nM.

UK51656 has an elimination half-life of 4.7 h, which is consistent with its duration of action in the anesthetized dog. The effect of UK51656 on coronary vascular resistance, has markedly long durations, being over 5 h[1].

[1]. Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91.