Tilapertin是甘氨酸转运蛋白1型(GlyT1)的口服抑制剂。
CAS：1000690-85-6
分子式：C20H21F3N2O2
分子量：378.39
纯度：98%
存储：Store at -20°C

Background:

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].

[1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97.