Glutaminyl Cyclase Inhibitor 3 (compound 212 ) 是一种具有抗阿尔兹海默症作用的化合物，是有效的人谷氨酰胺酰环化酶 (GC) 的抑制剂，其 IC50 值为 4.5 nM。Glutaminyl Cyclase-IN-1 (compound 212) 可显著降低大脑Aβ的浓度，并恢复认知功能。
CAS：2092921-50-9
分子式：C24H32N6O2S
分子量：468.61
纯度：98%
存储：Store at -20°C
Background:
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
IC50: 4.5 nM (hGC)[1].
[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer’s Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.
